DIABETES OUTBREAK DURING COVID19 LOCK-DOWN IN A PREDIABETIC PATIENT WITH CYSTIC FIBROSIS LONG TREATED WITH GLARGINE

Diabetes outbreak during COVID19 lock-down in a prediabetic patient with cystic fibrosis long treated with glargine

Abstract Background Cystic Fibrosis Related Diabetes (CFRD) is a frequent comorbidity of patients with Cystic Fibrosis (CF).A worsening of clinical conditions appears before CFRD.It has been demonstrated a decline in pulmonary function and nutritional status also in patients with prediabetes.Few trials show that insulin may be beneficial in prediab

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Stem cell-derived cardiomyocytes expressing a dominant negative pacemaker HCN4 channel do not reduce the risk of graft-related arrhythmias

BackgroundHuman pluripotent stem cell-derived cardiomyocytes (hPSC-CMs) show tremendous promise for cardiac regeneration following myocardial infarction (MI), but their transplantation gives rise to transient ventricular tachycardia (VT) in large-animal MI models, representing a major hurdle to translation.Our group previously reported that these a

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